What is the origin of Bugs Bunny's catchphrase, "What's up, doc?"?

Some current What's Up, Doc? Tip on Evaluation:
Query by reducer001: What is the origin of Bugs Bunny's catchphrase, "What's up, doc?"?
I'm asking yourself if this was a reference to a thing in pop culture at the time, or if it is original.


Very best answer:
Answer by plymlouisthe line was originally employed as a gag and became a punchline. it was supposed to be a lot more hip than saying what is cookin or what's up mac! i guess doc was slang for the time and was hip possibly even a tiny

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